ea0094oc6.5 | Metabolism, Obesity and Diabetes | SFEBES2023
Furigo Isadora
, Dearden Laura
, Pantaleao Lucas
, Ozanne Susan
In utero exposure to maternal obesity programs an increased risk of obesity. Animal models have shown that offspring obesity is often preceded by increased food intake, however, the mechanisms that mediate these changes are not understood. Using a mouse model of maternal diet-induced obesity we observed increased intake specifically of a high-fat pellet in adult offspring of obese mothers. Through small RNA sequencing, we identified programmed overexpression of miR-505-5p in t...